Compound Detail
CHEMBL5743989
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Basic Information
| ChEMBL ID | CHEMBL5743989 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NSIABHPIDIDJIU-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
445.9
MW (Da)
2.77
ALogP
8
HBA
2
HBD
132.1
PSA (Ų)
0.62
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.73
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thyroid hormone receptor beta CHEMBL1947 | EC50 | 6.73 | 6.73 | 188.0 | 1 |
| Thyroid hormone receptor alpha CHEMBL1860 | EC50 | 5.69 | 5.69 | 2049.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thyroid hormone receptor beta | EC50 | = | 188.0 | nM | 6.73 | Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for Thyroid... | - |
| Thyroid hormone receptor alpha | EC50 | = | 2049.0 | nM | 5.69 | Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for Thyroid... | - |
Data from ChEMBL 36 via Core Engine