Compound Detail
CHEMBL5761414
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Basic Information
| ChEMBL ID | CHEMBL5761414 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PKCVPDWHPSTUAV-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
458.1
MW (Da)
5.09
ALogP
3
HBA
2
HBD
66.8
PSA (Ų)
0.63
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 9.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thyroid hormone receptor beta CHEMBL1947 | EC50 | 9.06 | 9.06 | 0.9 | 1 |
| Thyroid hormone receptor alpha CHEMBL1860 | EC50 | 8.1 | 8.1 | 8.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thyroid hormone receptor beta | EC50 | = | 0.88 | nM | 9.06 | transactivation assay: Human epithelial kidney cells (HEK 293) were grown to 80%... | - |
| Thyroid hormone receptor alpha | EC50 | = | 7.96 | nM | 8.1 | transactivation assay: Human epithelial kidney cells (HEK 293) were grown to 80%... | - |
Data from ChEMBL 36 via Core Engine