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Compound Detail

CHEMBL5770003

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COc1cc2c(N3CCN(CCc4ccc5c(c4)CCC(=O)N5)CC3)cccc2s1

Basic Information

ChEMBL ID CHEMBL5770003
Phase Preclinical
Structure Type MOL
InChI Key LXQVLPLVRFYQOL-UHFFFAOYSA-N
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

421.6
MW (Da)
4.16
ALogP
5
HBA
1
HBD
44.8
PSA (Ų)
0.67
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H27N3O2S
MW 421.57
Aromatic Rings 3
Heavy Atoms 30
NP-Likeness -1.14

Activity Summary

IC50 2 meas. best 8.09
EC50 1 meas. best 8.89

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
5-hydroxytryptamine receptor 1A
CHEMBL214
EC50 8.89 8.89 1.3 1
D(2) dopamine receptor
CHEMBL217
IC50 8.09 8.09 8.1 1
5-hydroxytryptamine receptor 2A
CHEMBL224
IC50 5.98 5.98 1050.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine