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Compound Detail

CHEMBL5771063

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O=C1CCc2ccc(CCN3CCN(c4cccc5sccc45)CC3)cc2N1

Basic Information

ChEMBL ID CHEMBL5771063
Phase Preclinical
Structure Type MOL
InChI Key GPDSIVWKHXYNJS-UHFFFAOYSA-N
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

391.5
MW (Da)
4.15
ALogP
4
HBA
1
HBD
35.6
PSA (Ų)
0.73
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H25N3OS
MW 391.54
Aromatic Rings 3
Heavy Atoms 28
NP-Likeness -1.32

Activity Summary

IC50 3 meas. best 8.65
EC50 1 meas. best 9.03

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
5-hydroxytryptamine receptor 1A
CHEMBL214
EC50 9.03 9.03 0.9 1
D(2) dopamine receptor
CHEMBL217
IC50 8.65 8.355 2.2 2
5-hydroxytryptamine receptor 2A
CHEMBL224
IC50 6.77 6.77 169.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine