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Compound Detail

CHEMBL577183

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C=Cn1cc2c(nc(NC(=O)Nc3ccc(OC)cc3)n3nc(-c4ccco4)nc23)n1

Basic Information

ChEMBL ID CHEMBL577183
Phase Preclinical
Structure Type MOL
InChI Key KXCITGYLZAKTNE-UHFFFAOYSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

416.4
MW (Da)
3.49
ALogP
9
HBA
2
HBD
124.4
PSA (Ų)
0.45
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H16N8O3
MW 416.40
Aromatic Rings 5
Heavy Atoms 31
NP-Likeness -1.56

Activity Summary

Ki 4 meas. best 9.32

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
Ki 9.32 9.32 0.5 2
Adenosine receptor A2a
CHEMBL251
Ki 6.75 6.75 176.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19501513 10.1016/j.bmc.2009.05.038 Adenosine receptor A3 2
19501513 10.1016/j.bmc.2009.05.038 Adenosine receptor A2a 2

Data from ChEMBL 36 via Core Engine