Compound Detail
CHEMBL5772222
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C=CC(=O)Nc1cccc(F)c1Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)cc(OC)c2n1
Basic Information
| ChEMBL ID | CHEMBL5772222 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SYYYGOHNLIGMIE-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
543.4
MW (Da)
6.64
ALogP
7
HBA
2
HBD
94.6
PSA (Ų)
0.24
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 7.26 | 7.26 | 55.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 55.0 | nM | 7.26 | FGFR-1 wild type assay: In each well of a 384-well plate, 0.1 ng/ul of wild type... | - |
Data from ChEMBL 36 via Core Engine