Compound Detail
CHEMBL5772569
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CC(C)c1c(-c2cc(C(F)(F)F)c3ncnn3c2)[nH]c2ccc(C3CCN(CC#N)CC3)cc12
Basic Information
| ChEMBL ID | CHEMBL5772569 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UZTGVVJCFOFRAW-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
466.5
MW (Da)
5.72
ALogP
5
HBA
1
HBD
73.0
PSA (Ų)
0.39
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Toll-like receptor 7 CHEMBL5936 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
| Toll-like receptor 8 CHEMBL5805 | IC50 | 7.87 | 7.87 | 13.6 | 1 |
| Toll-like receptor 9 CHEMBL5804 | IC50 | 6.0 | 6.0 | 1001.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Toll-like receptor 7 | IC50 | = | 0.2 | nM | 9.7 | Biological Assay: HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or ... | - |
| Toll-like receptor 8 | IC50 | = | 13.6 | nM | 7.87 | Biological Assay: HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or ... | - |
| Toll-like receptor 9 | IC50 | = | 1001.0 | nM | 6.0 | Biological Assay: HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or ... | - |
Data from ChEMBL 36 via Core Engine