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Compound Detail

CHEMBL5783595

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CCn1cnnc1-c1cccc(N2Cc3c(cc(N4CCC[C@H]4C)nc3C(C)(C)N)C2=O)n1

Basic Information

ChEMBL ID CHEMBL5783595
Phase Preclinical
Structure Type MOL
InChI Key YEOMJKKERMIQSA-OAHLLOKOSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

446.6
MW (Da)
3.10
ALogP
8
HBA
1
HBD
106.1
PSA (Ų)
0.64
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H30N8O
MW 446.56
Aromatic Rings 3
Heavy Atoms 33
NP-Likeness -1.00

Activity Summary

IC50 2 meas. best 7.81

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Ribosomal protein S6 kinase alpha-2
CHEMBL3906
IC50 7.81 7.81 15.5 1
Serine/threonine-protein kinase D2
CHEMBL4900
IC50 7.29 7.29 51.2 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine