Compound Detail
CHEMBL578710
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CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(N)=O
Basic Information
| ChEMBL ID | CHEMBL578710 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | SUJPPMXJCZETOA-ZKEPBWIVSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1136.3
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.76
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Galanin receptor type 2 CHEMBL3176 | Ki | 8.76 | 8.76 | 1.7 | 1 |
| Galanin receptor type 1 CHEMBL4894 | Ki | 6.06 | 6.06 | 870.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Galanin receptor type 2 | Ki | = | 1.74 | nM | 8.76 | Binding affinity to human GalR2 | 20121116 |
| Galanin receptor type 1 | Ki | = | 870.0 | nM | 6.06 | Binding affinity to human GalR1 | 20121116 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20121116 | 10.1021/jm9018349 | Galanin receptor type 1 | 1 |
| 20121116 | 10.1021/jm9018349 | Galanin receptor type 2 | 1 |
Data from ChEMBL 36 via Core Engine