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Compound Detail

CHEMBL5807058

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COCCNc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)[C@H]4CCCN4C(C)=O)c(C=O)nc32)ncc1C#N

Basic Information

ChEMBL ID CHEMBL5807058
Phase Preclinical
Structure Type MOL
InChI Key WPPFSXSPXPNFAJ-XMMPIXPASA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

562.6
MW (Da)
2.17
ALogP
9
HBA
2
HBD
160.9
PSA (Ų)
0.34
QED
1
Ro5 Violations
9
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H34N8O5
MW 562.63
Aromatic Rings 2
Heavy Atoms 41
NP-Likeness -1.43

Activity Summary

IC50 1 meas. best 8.73

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Fibroblast growth factor receptor 4
CHEMBL3973
IC50 8.73 8.73 1.9 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine