Compound Detail
CHEMBL5812952
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Basic Information
| ChEMBL ID | CHEMBL5812952 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AFTKSWNHMAKIPE-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
327.3
MW (Da)
1.60
ALogP
6
HBA
2
HBD
80.5
PSA (Ų)
0.66
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 4 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| High affinity nerve growth factor receptor CHEMBL2815 | Kd | 9.7 | 9.7 | 0.2 | 2 |
| Tyrosine-protein kinase JAK2 CHEMBL2971 | Kd | 9.24 | 9.24 | 0.6 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| High affinity nerve growth factor receptor | Kd | = | 0.2 | nM | 9.7 | Kinase Binding Assays: Kinase binding assays were performed at DiscoveRx using t... | - |
| High affinity nerve growth factor receptor | Kd | = | 0.2 | nM | 9.7 | Kinase Binding Assays: Kinase binding assays were performed at DiscoveRx using t... | - |
| Tyrosine-protein kinase JAK2 | Kd | = | 0.57 | nM | 9.24 | Kinase Binding Assays: Kinase binding assays were performed at DiscoveRx using t... | - |
| Tyrosine-protein kinase JAK2 | Kd | = | 0.57 | nM | 9.24 | Kinase Binding Assays: Kinase binding assays were performed at DiscoveRx using t... | - |
Data from ChEMBL 36 via Core Engine