Compound Detail
CHEMBL5816107
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Basic Information
| ChEMBL ID | CHEMBL5816107 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DWRUMXZDNGCUDK-OAHLLOKOSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
399.4
MW (Da)
3.44
ALogP
5
HBA
2
HBD
81.0
PSA (Ų)
0.55
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ribosomal protein S6 kinase alpha-3 CHEMBL2345 | IC50 | 8.22 | 8.22 | 6.0 | 1 |
| Ribosomal protein S6 kinase alpha-6 CHEMBL4924 | IC50 | 8.1 | 8.1 | 8.0 | 1 |
| Ribosomal protein S6 kinase alpha-1 CHEMBL2553 | IC50 | 7.63 | 7.63 | 23.6 | 1 |
| Ribosomal protein S6 kinase alpha-2 CHEMBL3906 | IC50 | 4.03 | 4.03 | 94000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ribosomal protein S6 kinase alpha-3 | IC50 | = | 6.0 | nM | 8.22 | Kinase Assay: Radioisotope assays (SignalChem) were performed for the evaluation... | - |
| Ribosomal protein S6 kinase alpha-6 | IC50 | = | 8.0 | nM | 8.1 | Kinase Assay: Radioisotope assays (SignalChem) were performed for the evaluation... | - |
| Ribosomal protein S6 kinase alpha-1 | IC50 | = | 23.6 | nM | 7.63 | Kinase Assay: Radioisotope assays (SignalChem) were performed for the evaluation... | - |
| Ribosomal protein S6 kinase alpha-2 | IC50 | = | 94000.0 | nM | 4.03 | Kinase Assay: Radioisotope assays (SignalChem) were performed for the evaluation... | - |
Data from ChEMBL 36 via Core Engine