Compound Detail
CHEMBL5816973
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C=CC(=O)N1CCN(CCCn2c(=O)c(-c3c(Cl)c(O)cc(OC)c3Cl)cc3cnc(NC)nc32)CC1
Basic Information
| ChEMBL ID | CHEMBL5816973 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GZXSHRIQPUPWSR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
547.4
MW (Da)
3.24
ALogP
9
HBA
2
HBD
112.8
PSA (Ų)
0.41
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 9.1 | 9.1 | 0.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 0.8 | nM | 9.1 | Enzymatic Activity Assay: A Caliper-based kinase assay (Caliper Life Sciences, H... | - |
Data from ChEMBL 36 via Core Engine