Compound Detail
CHEMBL5822079
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Basic Information
| ChEMBL ID | CHEMBL5822079 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PCAMJUDIUZGFAB-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
417.3
MW (Da)
5.06
ALogP
5
HBA
1
HBD
72.8
PSA (Ų)
0.36
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-dependent 3',5'-cyclic phosphodiesterase CHEMBL2652 | IC50 | 7.92 | 7.92 | 12.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-dependent 3',5'-cyclic phosphodiesterase | IC50 | = | 12.0 | nM | 7.92 | PDE2 Inhibition In Vitro Assay: Assay: PDE2A is assayed with FL-cAMP as substrat... | - |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | IC50 | = | 12.0 | nM | 7.92 | Measurement of PDE2 Inhibition In Vitro: r-hPDE2A (Accession No. NM_002599, Homo... | - |
Data from ChEMBL 36 via Core Engine