Compound Detail
CHEMBL5830381
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Basic Information
| ChEMBL ID | CHEMBL5830381 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ATVSJBNYFPDFLL-UHFFFAOYSA-N |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
468.6
MW (Da)
4.57
ALogP
7
HBA
2
HBD
127.7
PSA (Ų)
0.45
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 8.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 8.22 | 7.4433 | 6.0 | 3 |
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 7.77 | 7.055 | 17.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 6.0 | nM | 8.22 | VEGFR2 Cellular Assay: Automated FLIPR (Fluorometric Imaging Plate Reader) techn... | - |
| Platelet-derived growth factor receptor beta | IC50 | = | 17.0 | nM | 7.77 | Biochemical Assay: Biochemical PDGFRβ kinase assays were performed in 96 well mi... | - |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 17.0 | nM | 7.77 | VEGFR2 Kinase Assay: Biochemical KDR kinase assays were performed in 96 well mic... | - |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 457.0 | nM | 6.34 | Biochemical Assay: Biochemical KDR kinase assays were performed in 96 well micro... | - |
| Platelet-derived growth factor receptor beta | IC50 | = | 457.0 | nM | 6.34 | PDGFRbeta Kinase Assay: Biochemical PDGFRβ kinase assays were performed in 96 we... | - |
Data from ChEMBL 36 via Core Engine