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Compound Detail

CHEMBL583672

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CN(C)c1ccc(/C=C/C2=NCCc3cc(Cl)c(O)cc3N2c2ccccc2)cc1

Basic Information

ChEMBL ID CHEMBL583672
Phase Preclinical
Structure Type MOL
InChI Key FATROPVSFPNWPE-JLHYYAGUSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

417.9
MW (Da)
5.92
ALogP
4
HBA
1
HBD
39.1
PSA (Ų)
0.57
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H24ClN3O
MW 417.94
Aromatic Rings 3
Heavy Atoms 30
NP-Likeness -0.45

Activity Summary

Ki 1 meas. best 6.81

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
No relevant target
CHEMBL2362975
Ki 6.81 6.81 154.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
No relevant target Ki = 154.0 nM 6.81 Ionization constant for the compound (pKa) 19643610

Literature References

PubMed DOI Target Context # Activities
19643610 10.1016/j.bmcl.2009.07.012 No relevant target 1
19643610 10.1016/j.bmcl.2009.07.012 Unchecked 1

Data from ChEMBL 36 via Core Engine