Assay Detail
Physicochemical
CHEMBL1047148
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ionization constant for the compound (pKa)
26
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Physicochemical |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Intermediate |
Publication
Design and discovery of 1,3-benzodiazepines as novel dopamine antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.54 | 9.00 |
| pKa | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 9.00 |
| CHEMBL340006 | — | — | 1 | 7.30 |
| CHEMBL578122 | — | — | 1 | 7.06 |
| CHEMBL584208 | — | — | 1 | 6.89 |
| CHEMBL583672 | — | — | 1 | 6.81 |
| CHEMBL583467 | — | — | 1 | 6.74 |
| CHEMBL577050 | — | — | 1 | 6.70 |
| CHEMBL583890 | — | — | 1 | 6.70 |
| CHEMBL577540 | — | — | 1 | 6.69 |
| CHEMBL565946 | — | — | 1 | 6.55 |
| CHEMBL577266 | — | — | 1 | 6.51 |
| CHEMBL576617 | — | — | 1 | 6.49 |
| CHEMBL568459 | — | — | 1 | 6.43 |
| CHEMBL576458 | — | — | 1 | 6.41 |
| CHEMBL568030 | — | — | 1 | 6.36 |
| CHEMBL578800 | — | — | 1 | 6.35 |
| CHEMBL568251 | — | — | 1 | 6.33 |
| CHEMBL568031 | — | — | 1 | 6.32 |
| CHEMBL571061 | — | — | 1 | 6.24 |
| CHEMBL577473 | — | — | 1 | 6.11 |
| CHEMBL578571 | — | — | 1 | 6.05 |
| CHEMBL568246 | — | — | 1 | 6.03 |
| CHEMBL577267 | — | — | 1 | 5.82 |
| CHEMBL570836 | — | — | 1 | 4.99 |
| CHEMBL14047 | PHENYLGUANIDINE | — | 1 | - |
| CHEMBL570835 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL340006 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL578122 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL584208 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL583672 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL583467 | — | Ki | = | 181.0 | nM | 6.74 |
| CHEMBL577050 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL583890 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL577540 | — | Ki | = | 206.0 | nM | 6.69 |
| CHEMBL565946 | — | Ki | = | 284.0 | nM | 6.55 |
| CHEMBL577266 | — | Ki | = | 311.0 | nM | 6.51 |
| CHEMBL576617 | — | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL568459 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL576458 | — | Ki | = | 391.0 | nM | 6.41 |
| CHEMBL568030 | — | Ki | = | 442.0 | nM | 6.36 |
| CHEMBL578800 | — | Ki | = | 445.0 | nM | 6.35 |
| CHEMBL568251 | — | Ki | = | 465.0 | nM | 6.33 |
| CHEMBL568031 | — | Ki | = | 475.0 | nM | 6.32 |
| CHEMBL571061 | — | Ki | = | 575.0 | nM | 6.24 |
| CHEMBL577473 | — | Ki | = | 783.0 | nM | 6.11 |
| CHEMBL578571 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL568246 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL577267 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL570836 | — | Ki | = | 10200.0 | nM | 4.99 |
| CHEMBL14047 | PHENYLGUANIDINE | pKa | = | 10.8 | — | - |
| CHEMBL570835 | — | pKa | = | 8.9 | — | - |