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Compound Detail

CHEMBL5843900

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CC[C@@H](N)c1nc(N(C)C(C)C)cc2c1CN(c1cccc(-c3nnc4n3[C@@H](C)CC4)n1)C2=O

Basic Information

ChEMBL ID CHEMBL5843900
Phase Preclinical
Structure Type MOL
InChI Key WDXXELAFEZBSNE-MAUKXSAKSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

460.6
MW (Da)
3.66
ALogP
8
HBA
1
HBD
106.1
PSA (Ų)
0.60
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H32N8O
MW 460.59
Aromatic Rings 3
Heavy Atoms 34
NP-Likeness -0.85

Activity Summary

IC50 2 meas. best 7.27

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Ribosomal protein S6 kinase alpha-2
CHEMBL3906
IC50 7.27 7.27 53.5 1
Serine/threonine-protein kinase D2
CHEMBL4900
IC50 6.6 6.6 251.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine