Compound Detail
CHEMBL5844085
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C=CC(=O)N[C@@H]1CCCN(CCn2c(=O)c(-c3c(Cl)c(OC)cc(OC)c3Cl)cc3cnc(NCC)nc32)C1
Basic Information
| ChEMBL ID | CHEMBL5844085 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MMLLVULVKWXOPN-QGZVFWFLSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
575.5
MW (Da)
3.98
ALogP
9
HBA
2
HBD
110.6
PSA (Ų)
0.35
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.85 | 8.85 | 1.4 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 1.4 | nM | 8.85 | Caliper-Based Kinase Assay: A Caliper-based kinase assay (Caliper Life Sciences,... | - |
| Fibroblast growth factor receptor 1 | IC50 | = | 1.4 | nM | 8.85 | Enzymatic Activity Assay: A Caliper-based kinase assay (Caliper Life Sciences, H... | - |
Data from ChEMBL 36 via Core Engine