Compound Detail
CHEMBL5844881
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CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)c3cccc4c3ccn4C(=O)NC3C[C@@H](C(=O)NC4CCCc5ccccc54)N(C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C3)ccc2C[C@H]1C(=O)NC1CCCc2ccccc21)C(C)(C)C
Basic Information
| ChEMBL ID | CHEMBL5844881 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PSDYJXNDCNNPNS-FAHIUXGWSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
1146.5
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Baculoviral IAP repeat-containing protein 2/Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP CHEMBL6066574 | IC50 | 7.68 | 7.68 | 21.0 | 1 |
| Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP CHEMBL6066573 | IC50 | 7.12 | 7.12 | 76.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Baculoviral IAP repeat-containing protein 2/Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP | IC50 | = | 21.0 | nM | 7.68 | Homogeneous Time Resolved Fluorescence (HTRF) Assay: Assays were performed in bl... | - |
| Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP | IC50 | = | 76.0 | nM | 7.12 | Homogeneous Time Resolved Fluorescence (HTRF) Assay: Assays were performed in bl... | - |
Data from ChEMBL 36 via Core Engine