Compound Detail
CHEMBL5846455
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Basic Information
| ChEMBL ID | CHEMBL5846455 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AQVFAJITBRMHAU-UHFFFAOYSA-N |
1
Targets
6
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
424.3
MW (Da)
5.16
ALogP
5
HBA
3
HBD
78.9
PSA (Ų)
0.48
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 7.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 7.26 | 6.9267 | 55.0 | 6 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 55.0 | nM | 7.26 | Omnia Assay: EGFR (WT) and EGFR (T790M/L858R): The Omnia Assay Protocol for pote... | - |
| Epidermal growth factor receptor | IC50 | = | 55.0 | nM | 7.26 | Omnia Assay: EGFR (WT) and EGFR (T790M/L858R): The Omnia Assay Protocol for pote... | - |
| Epidermal growth factor receptor | IC50 | = | 55.0 | nM | 7.26 | Omnia Assay Protocol : Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen a... | - |
| Epidermal growth factor receptor | IC50 | = | 55.0 | nM | 7.26 | Omnia Assay Protocol : Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen a... | - |
| Epidermal growth factor receptor | IC50 | = | 550.0 | nM | 6.26 | Omnia Assay: Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T7... | - |
| Epidermal growth factor receptor | IC50 | = | 550.0 | nM | 6.26 | Omnia Assay: Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T7... | - |
Data from ChEMBL 36 via Core Engine