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Compound Detail

CHEMBL5847452

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NC(=O)[C@@H]1CCCN1c1ccc2c(c1)OCCn1cc(-c3ncnn3CC(F)(F)F)nc1-2

Basic Information

ChEMBL ID CHEMBL5847452
Phase Preclinical
Structure Type MOL
InChI Key JANGZKOHBDPUSU-HNNXBMFYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

447.4
MW (Da)
2.22
ALogP
8
HBA
1
HBD
104.1
PSA (Ų)
0.66
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H20F3N7O2
MW 447.42
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness -1.25

Activity Summary

Ki 2 meas. best 9.41

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
CHEMBL3130
Ki 9.41 9.41 0.4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
CHEMBL3267
Ki 9.41 9.41 0.4 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine