Compound Detail
CHEMBL584766
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Basic Information
| ChEMBL ID | CHEMBL584766 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KPJNSSGIUKWMPK-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
1
PK Parameters
6
Publications
0
Known Names
Molecular Properties
421.6
MW (Da)
4.82
ALogP
6
HBA
0
HBD
56.0
PSA (Ų)
0.61
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.64
IC50 1 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL264 | Ki | 7.64 | 7.64 | 23.0 | 2 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 7.0 | 7.0 | 101.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 339.0 | ng.hr.mL-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | Ki | = | 23.0 | nM | 7.64 | Displacement of [3H]N-alpha-methylhistamine from human recombinant histamine H3 ... | 19773164 |
| Histamine H3 receptor | Ki | = | 23.0 | nM | 7.64 | Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor ... | 21802950 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 101.01 | nM | 7.0 | Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding... | 21802950 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19773164 | 10.1016/j.bmcl.2009.09.006 | Histamine H3 receptor | 1 |
| 19773164 | 10.1016/j.bmcl.2009.09.006 | Rattus norvegicus | 1 |
| 19773164 | 10.1016/j.bmcl.2009.09.006 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 21802950 | 10.1016/j.bmcl.2011.07.006 | No relevant target | 1 |
| 21802950 | 10.1016/j.bmcl.2011.07.006 | Histamine H3 receptor | 1 |
| 21802950 | 10.1016/j.bmcl.2011.07.006 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
Data from ChEMBL 36 via Core Engine