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Compound Detail

CHEMBL5855529

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Cc1nn(C)c2nc(N(CCO)NC(=O)Nc3cc(Cl)cc(C(F)(F)F)c3)cc(C(C)C)c12

Basic Information

ChEMBL ID CHEMBL5855529
Phase Preclinical
Structure Type MOL
InChI Key DQFTUNJTYRFPQS-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

484.9
MW (Da)
4.61
ALogP
6
HBA
3
HBD
95.3
PSA (Ų)
0.44
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H24ClF3N6O2
MW 484.91
Aromatic Rings 3
Heavy Atoms 33
NP-Likeness -1.68

Activity Summary

IC50 1 meas. best 7.13

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sphingosine 1-phosphate receptor 5
CHEMBL2274
IC50 7.13 7.13 74.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine