Compound Detail
CHEMBL5870740
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C=CC(=O)Nc1ccccc1Nc1ncc(Cl)c(N2CCN(C(=O)Nc3cccc(C(F)(F)F)c3)CC2)n1
Basic Information
| ChEMBL ID | CHEMBL5870740 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IXOYJOXOYULUSR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
546.0
MW (Da)
5.37
ALogP
6
HBA
3
HBD
102.5
PSA (Ų)
0.36
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 6.26 | 6.26 | 550.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 | IC50 | = | 550.0 | nM | 6.26 | FGFR-4 wild type assay: In each well of a 384-well plate, 0.5 ng/ul of wild type... | - |
Data from ChEMBL 36 via Core Engine