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Compound Detail

CHEMBL5872027

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O=S(=O)(Nc1ccc(F)cn1)c1cc(F)c(OC[C@@H]2CNCCC2c2ccc(Cl)cc2)cc1F

Basic Information

ChEMBL ID CHEMBL5872027
Phase Preclinical
Structure Type MOL
InChI Key VIKCAELOKQWDBV-BUSXIPJBSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

511.9
MW (Da)
4.73
ALogP
5
HBA
2
HBD
80.3
PSA (Ų)
0.48
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H21ClF3N3O3S
MW 511.95
Aromatic Rings 3
Heavy Atoms 34
NP-Likeness -1.14

Activity Summary

IC50 1 meas. best 7.15

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 7.15 7.15 70.5 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 70.5 nM 7.15 Electrophysiological Assay : The following patch voltage clamp electrophysiology... -

Data from ChEMBL 36 via Core Engine