Compound Detail
CHEMBL5874026
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Basic Information
| ChEMBL ID | CHEMBL5874026 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RCZJEMPRLHUVEZ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
465.5
MW (Da)
3.84
ALogP
8
HBA
2
HBD
131.7
PSA (Ų)
0.30
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase BTK CHEMBL5251 | IC50 | 8.36 | 8.34 | 4.4 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase BTK | IC50 | = | 4.4 | nM | 8.36 | Caliper-based kinase assay: A Caliper-based kinase assay (Caliper Life Sciences,... | - |
| Tyrosine-protein kinase BTK | IC50 | = | 4.8 | nM | 8.32 | Enzymatic Activity Assay: A Caliper-based kinase assay (Caliper Life Sciences, H... | - |
Data from ChEMBL 36 via Core Engine