Compound Detail
CHEMBL5875388
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CC(C)c1ccc(S(=O)(=O)[C@H]2CN(S(=O)(=O)c3ccc(C#N)cc3Cl)C[C@@]2(O)CO)cc1
Basic Information
| ChEMBL ID | CHEMBL5875388 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JZGRQLRHWWZWLY-LEWJYISDSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
499.0
MW (Da)
1.91
ALogP
7
HBA
2
HBD
135.8
PSA (Ų)
0.62
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 4 CHEMBL3119 | IC50 | 7.26 | 7.26 | 55.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 4 | IC50 | = | 55.0 | nM | 7.26 | FLIPR Assay for hTRPV4 Expressed in BHK Cells: TRPV4 channel activation results ... | - |
Data from ChEMBL 36 via Core Engine