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Compound Detail

CHEMBL5879939

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CC[C@H]1CCc2nnc(-c3cccc(N4Cc5c(cc(N6CCC[C@H]6C)nc5CNC)C4=O)n3)n21

Basic Information

ChEMBL ID CHEMBL5879939
Phase Preclinical
Structure Type MOL
InChI Key QHBRARNRIAKCGO-SJORKVTESA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

472.6
MW (Da)
3.50
ALogP
8
HBA
1
HBD
92.1
PSA (Ų)
0.59
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H32N8O
MW 472.60
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -0.79

Activity Summary

IC50 2 meas. best 8.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Serine/threonine-protein kinase D2
CHEMBL4900
IC50 8.1 8.1 8.0 1
Ribosomal protein S6 kinase alpha-2
CHEMBL3906
IC50 8.0 8.0 10.1 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine