Compound Detail
CHEMBL5885719
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Basic Information
| ChEMBL ID | CHEMBL5885719 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KGUOYCPINMKTEY-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
476.2
MW (Da)
4.70
ALogP
4
HBA
3
HBD
88.2
PSA (Ų)
0.56
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cystic fibrosis transmembrane conductance regulator CHEMBL4051 | EC50 | 7.05 | 7.0 | 90.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cystic fibrosis transmembrane conductance regulator | EC50 | = | 90.0 | nM | 7.05 | Potentiator Assay: Fischer Rat Thyroid (FRT) epithelial cells, stably expressing... | - |
| Cystic fibrosis transmembrane conductance regulator | EC50 | = | 112.0 | nM | 6.95 | Potentiator Assay: Fischer Rat Thyroid (FRT) epithelial cells, stably expressing... | - |
Data from ChEMBL 36 via Core Engine