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Compound Detail

CHEMBL5887095

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CCC1CCc2c(sc(NC(=O)C3=C(C(=O)O)CCCC3)c2-c2nc(C)cs2)C1

Basic Information

ChEMBL ID CHEMBL5887095
Phase Preclinical
Structure Type MOL
InChI Key ZQCSYWFCRBAVSD-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

430.6
MW (Da)
5.59
ALogP
5
HBA
2
HBD
79.3
PSA (Ų)
0.65
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H26N2O3S2
MW 430.60
Aromatic Rings 2
Heavy Atoms 29
NP-Likeness -1.24

Activity Summary

IC50 2 meas. best 8.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Fatty acid-binding protein 5
CHEMBL3674
IC50 8.0 8.0 10.0 1
Fatty acid-binding protein, adipocyte
CHEMBL2083
IC50 7.06 7.06 88.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine