Compound Detail
CHEMBL589092
FENTIAZAC 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL589092 |
| Name | FENTIAZAC |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | JIEKMACRVQTPRC-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
12
Publications
5
Known Names
3
Indications
Molecular Properties
329.8
MW (Da)
4.76
ALogP
3
HBA
1
HBD
50.2
PSA (Ų)
0.75
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Arthralgia Myalgia Rheumatic Diseases
ATC Classification
M01AB10
fentiazac
Level 1: MUSCULO-SKELETAL SYSTEM
Level 2: ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M02AA14
fentiazac
Level 1: MUSCULO-SKELETAL SYSTEM
Level 2: TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Activity Summary
IC50 4 meas. best 6.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin D2 receptor 2 CHEMBL5071 | IC50 | 6.26 | 6.2 | 550.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prostaglandin D2 receptor 2 | IC50 | = | 550.0 | nM | 6.26 | Displacement of[3H]PGD2 from human CRTH2 receptor expressed in HEK385-7 cells | 20022749 |
| Prostaglandin D2 receptor 2 | IC50 | = | 550.0 | nM | 6.26 | Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed... | 20031403 |
| Prostaglandin D2 receptor 2 | IC50 | = | 550.0 | nM | 6.26 | Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green mon... | 20031403 |
| Prostaglandin D2 receptor 2 | IC50 | = | 960.0 | nM | 6.02 | Antagonist activity at human CRTH2 receptor expressed in HEK285-7 cells assessed... | 20022749 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15646539 | 10.1016/s0399-8320(04)95062-2 | Unchecked | 11 |
| 15646539 | 10.1016/s0399-8320(04)95062-2 | NON-PROTEIN TARGET | 8 |
| 20022749 | 10.1016/j.bmcl.2009.12.015 | Prostaglandin D2 receptor 2 | 3 |
| 20031403 | 10.1016/j.bmcl.2009.12.008 | Prostaglandin D2 receptor 2 | 3 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 23122865 | 10.1016/j.bmcl.2012.10.010 | Indoleamine 2,3-dioxygenase 2 | 1 |
| - | 10.1101/2020.04.03.023846 | SARS-CoV-2 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 38318365 | 10.1016/j.isci.2024.108907 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 1 |
Data from ChEMBL 36 via Core Engine