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Compound Detail

CHEMBL589786

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CC[Si](C)(C)c1ccc(CNC(=S)N[C@H](C)c2ccc(NS(C)(=O)=O)cc2)cc1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL589786
Phase Preclinical
Structure Type MOL
InChI Key YNNBAQCTJGSISN-MRXNPFEDSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

449.7
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H31N3O2S2Si
MW 449.72

Activity Summary

IC50 1 meas. best 6.17

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Transient receptor potential cation channel subfamily V member 1
CHEMBL5102
 IC50 6.17 6.17 670.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Transient receptor potential cation channel subfamily V member 1 IC50 = 670.0 nM 6.17 Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduct... 19931463

Literature References

PubMed DOI Target Context # Activities
19931463 10.1016/j.bmc.2009.11.014 Transient receptor potential cation channel subfamily V member 1 2

Data from ChEMBL 36 via Core Engine