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Compound Detail

CHEMBL5907342

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N#Cc1ccc(Oc2cn[nH]c2-c2cccc(O)c2F)cc1

Basic Information

ChEMBL ID CHEMBL5907342
Phase Preclinical
Structure Type MOL
InChI Key ILICJNIOKFHPQK-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

295.3
MW (Da)
3.59
ALogP
4
HBA
2
HBD
81.9
PSA (Ų)
0.77
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H10FN3O2
MW 295.27
Aromatic Rings 3
Heavy Atoms 22
NP-Likeness -1.14

Activity Summary

EC50 2 meas. best 10.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cytochrome P450 11B1, mitochondrial
CHEMBL1908
EC50 10.77 10.77 0.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine