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Target Snapshot

CHEMBL1908 Target Snapshot

Cytochrome P450 11B1, mitochondrial · SINGLE PROTEIN · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
2,114Compounds
113Assays
7Approved Drugs
2,641.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Cytochrome P450 11B1, mitochondrial shows approved-linked disease relevance led by Cushing syndrome. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P15538. Start with Cushing syndrome, then reuse UniProt P15538 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with Cushing syndrome, then reuse UniProt P15538 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 3 linked drugs
Open source guide
Disease program
Cushing syndrome

Cytochrome P450 11B1, mitochondrial shows approved-linked disease relevance led by Cushing syndrome. 5 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.

Start review with Cushing syndrome because it currently carries approved-linked support. Linked drugs include LEVOKETOCONAZOLE, METYRAPONE, OSILODROSTAT PHOSPHATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 3 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cytochrome P450 11B1, mitochondrial as ChEMBL target CHEMBL1908, mapped to UniProt P15538. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cytochrome P450 11B1, mitochondrial
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1908
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P15538
Cytochrome P450 11B1, mitochondrial
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cytochrome P450 11B1, mitochondrial is the right protein anchor across sources, using UniProt P15538 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why Cushing syndrome is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameCytochrome P450 11B1, mitochondrial
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP15538
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCytochrome P450 11B1, mitochondrial
UniProt AccessionP15538
Component TypeProtein
Sequence Length503 aa

Cytochrome P450 11B1, mitochondrial

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Cytochrome P450 11B1, mitochondrial, mapped to UniProt P15538. Sequence length is 503 aa.

Mapped IDP15538
Review nameCytochrome P450 11B1, mitochondrial
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Cytochrome P450 11B1, mitochondrial shows approved-linked disease relevance led by Cushing syndrome. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
Cushing syndrome
3 linked drugs · 3 direct · 3 efficacy
Linked drugLEVOKETOCONAZOLE
Linked drugMETYRAPONE
Linked drugOSILODROSTAT PHOSPHATE
Approved-linked Approved
pituitary-dependent Cushing's disease
2 linked drugs · 2 direct · 2 efficacy
Linked drugLEVOKETOCONAZOLE
Linked drugOSILODROSTAT PHOSPHATE
Approved-linked Approved
adrenal cortex carcinoma
1 linked drug · 1 direct · 1 efficacy
Linked drugMITOTANE
Approved-linked Approved
adrenal cortex neoplasm
1 linked drug · 1 direct · 1 efficacy
Linked drugMITOTANE
Approved-linked Approved
adrenal gland disease
1 linked drug · 1 direct · 1 efficacy
Linked drugLEVOKETOCONAZOLE
Approved-linked Approved
adrenal gland hyperfunction
1 linked drug · 1 direct · 1 efficacy
Linked drugLEVOKETOCONAZOLE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with Cushing syndrome because it currently carries approved-linked support. Linked drugs include LEVOKETOCONAZOLE, METYRAPONE, OSILODROSTAT PHOSPHATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseCushing syndrome
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

7
Approved
2
Phase III
4
Phase II
Assay Mix

Activity Type Distribution

IC502,128.0
KI2.0
EC50511.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5784805 10.96 EC50 0.011 Preclinical
CHEMBL5873523 10.96 EC50 0.011 Preclinical
CHEMBL5784706 10.92 EC50 0.012 Preclinical
CHEMBL5907342 10.77 EC50 0.017 Preclinical
CHEMBL5770375 10.74 EC50 0.018 Preclinical
CHEMBL5925574 10.55 EC50 0.028 Preclinical
CHEMBL6020579 10.51 EC50 0.031 Preclinical
CHEMBL5965994 10.49 EC50 0.032 Preclinical
CHEMBL5876457 10.44 EC50 0.036 Preclinical
CHEMBL5754409 10.42 EC50 0.038 Preclinical
Distribution

pChEMBL Value Distribution

283
5.0
298
5.5
416
6.0
318
6.5
229
7.0
209
7.5
125
8.0
64
8.5
43
9.0
18
9.5
pChEMBL
Approved Drugs

Approved Drugs

OSILODROSTAT
CHEMBL3099695
Approved 2020
Properties Compare Identifier
POSACONAZOLE
CHEMBL1397
Approved 2005
Properties Compare Identifier
ETOMIDATE
CHEMBL681
Approved 1982
Properties Compare Identifier
KETOCONAZOLE
CHEMBL157101
Approved 1981
Properties Compare Identifier
METYRAPONE
CHEMBL934
Approved 1961
Properties Compare Identifier
Assay Landscape

Assay Landscape

113
Total Assays
1,597
Tested Compounds
3
Assay Types
Binding — 95 assays, 1,597 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 64 970 6.7
assay format 22 469 6.6
single protein format 9 158 5.4
ADME — 16 assays, 237 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 12 224 6.5
single protein format 3 11 6.7
assay format 1 2 5.5
Functional — 2 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 4 4.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine