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Evidence Snapshot

Cytochrome P450 11B1, mitochondrial

CHEMBL1908 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:19:48Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL1908
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cytochrome P450 11B1, mitochondrial as ChEMBL target CHEMBL1908, mapped to UniProt P15538. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cytochrome P450 11B1, mitochondrial
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL1908
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P15538
Cytochrome P450 11B1, mitochondrial
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Cytochrome P450 11B1, mitochondrial matters

As of 2026-09-13

Cytochrome P450 11B1, mitochondrial is reviewed as Cytochrome P450 11B1, mitochondrial (UniProt P15538); Cytochrome P450 11B1, mitochondrial shows approved-linked disease relevance led by Cushing syndrome. 5 more disease programs remain visible in the same review block.; 3 linked drugs keep this evidence frame grounded.; the current evidence base includes 7 approved drugs, 2114 compounds, and 113 assays, with lead potency reaching pChEMBL 11.0.

Disease context
Cushing syndrome

Cytochrome P450 11B1, mitochondrial shows approved-linked disease relevance led by Cushing syndrome. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the rationale reviewable. 5 additional disease programs remain visible in the same card. Linked drugs include LEVOKETOCONAZOLE, METYRAPONE, OSILODROSTAT PHOSPHATE.

Start review with Cushing syndrome because it currently carries approved-linked support. Linked drugs include LEVOKETOCONAZOLE, METYRAPONE, OSILODROSTAT PHOSPHATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Approved-linked 3 linked drugs
Activity base
Portfolio and assay base

ChEMBL currently tracks 7 approved drugs, 2114 compounds, and 113 assays for this target. The dominant activity type is IC50. CHEMBL5784805 is the current potency anchor at pChEMBL 11.0.

Use CHEMBL5784805 as the tractability anchor when discussing potency (pChEMBL 11.0).

Activity source · ChEMBL 36 via Core Engine
7 approved pChEMBL 11.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Cytochrome P450 11B1, mitochondrial matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P15538, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need to see why Cushing syndrome is currently treated as approved-linked support.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

2114
Total Compounds
113
Total Assays
7
Approved Drugs
IC50: 2128.0, KI: 2.0, EC50: 511.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL5784805
 11.0 EC50 —
No preferred name
CHEMBL5873523
 11.0 EC50 —
No preferred name
CHEMBL5784706
 10.9 EC50 —
No preferred name
CHEMBL5907342
 10.8 EC50 —
No preferred name
CHEMBL5770375
 10.7 EC50 —

Approved Drugs

Structure Compound First Approval
OSILODROSTAT
CHEMBL3099695
 2020
POSACONAZOLE
CHEMBL1397
 2005
ETOMIDATE
CHEMBL681
 1982
KETOCONAZOLE
CHEMBL157101
 1981
METYRAPONE
CHEMBL934
 1961
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:19:48Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL1908