Compound Detail
CHEMBL5911168
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Basic Information
| ChEMBL ID | CHEMBL5911168 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RIHUQGLIJOYTGB-UHFFFAOYSA-N |
1
Targets
7
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
385.9
MW (Da)
4.03
ALogP
5
HBA
1
HBD
77.2
PSA (Ų)
0.66
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 7.29
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Monocarboxylate transporter 4 CHEMBL2073663 | IC50 | 7.29 | 6.692 | 51.0 | 5 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Monocarboxylate transporter 4 | IC50 | = | 51.0 | nM | 7.29 | Assay 2: MCT4-Mediated Lactate Transport in NCI-H358 Lung Adenocarcinoma Cells: ... | - |
| Monocarboxylate transporter 4 | IC50 | = | 51.0 | nM | 7.29 | MCT4-Mediated Lactate Transport in NCI-H358 Lung Adenocarcinoma Cell: NCI-H358 l... | - |
| Monocarboxylate transporter 4 | IC50 | = | 250.0 | nM | 6.6 | Lactate Transport in MCT4-Expressing MDA-MB-453 Breast Cancer Cells: MCT4 may be... | - |
| Monocarboxylate transporter 4 | IC50 | = | 250.0 | nM | 6.6 | Lactate Transport in MCT4-Expressing MDA-MB-453 Breast Cancer Cells: MCT4 may be... | - |
| Monocarboxylate transporter 4 | IC50 | = | 2100.0 | nM | 5.68 | Biological Activity Assay 2: NCI-H358 lung adenocarcinoma cells may be used to m... | - |
Data from ChEMBL 36 via Core Engine