Compound Detail
CHEMBL5924493
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC(C)C(NC(=O)CN1CCC(O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O)C(=O)N(C)C
Basic Information
| ChEMBL ID | CHEMBL5924493 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DWDZSYDWDXXGPB-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
470.9
MW (Da)
0.29
ALogP
5
HBA
3
HBD
119.0
PSA (Ų)
0.47
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Methionine aminopeptidase 2 CHEMBL3922 | IC50 | 6.62 | 5.83 | 240.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Methionine aminopeptidase 2 | IC50 | = | 240.0 | nM | 6.62 | Activity Assay: The MetAP-2 activity is determined by coupling enzymatic reactio... | - |
| Methionine aminopeptidase 2 | IC50 | = | 9100.0 | nM | 5.04 | Activity Assay: The MetAP-2 activity is determined by coupling enzymatic reactio... | - |
Data from ChEMBL 36 via Core Engine