Compound Detail
CHEMBL5924926
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Basic Information
| ChEMBL ID | CHEMBL5924926 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HYLKKLYLLQUXPF-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
379.5
MW (Da)
1.85
ALogP
8
HBA
3
HBD
92.7
PSA (Ų)
0.64
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 4 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta CHEMBL5554 | Kd | 8.1 | 8.1 | 8.0 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform CHEMBL3130 | Kd | 7.47 | 7.47 | 34.0 | 1 |
| Serine/threonine-protein kinase mTOR CHEMBL2842 | Kd | 4.77 | 4.77 | 16982.0 | 1 |
| Unchecked CHEMBL612545 | Kd | 4.68 | 4.68 | 20893.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta | Kd | = | 8.0 | nM | 8.1 | KINOMEscan Enzyme Binding Assays: Kinase enzyme binding affinities of compounds ... | - |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Kd | = | 34.0 | nM | 7.47 | KINOMEscan Enzyme Binding Assays: Kinase enzyme binding affinities of compounds ... | - |
| Serine/threonine-protein kinase mTOR | Kd | = | 16982.0 | nM | 4.77 | KINOMEscan Enzyme Binding Assays: Kinase enzyme binding affinities of compounds ... | - |
| Unchecked | Kd | = | 20893.0 | nM | 4.68 | KINOMEscan Enzyme Binding Assays: Kinase enzyme binding affinities of compounds ... | - |
Data from ChEMBL 36 via Core Engine