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Compound Detail

CHEMBL5945545

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O=C1Cc2cc(CCN3CCN(c4cccc5sc(F)cc45)CC3)ccc2N1

Basic Information

ChEMBL ID CHEMBL5945545
Phase Preclinical
Structure Type MOL
InChI Key NTNZQIYNYUYERV-UHFFFAOYSA-N
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

395.5
MW (Da)
3.90
ALogP
4
HBA
1
HBD
35.6
PSA (Ų)
0.73
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H22FN3OS
MW 395.50
Aromatic Rings 3
Heavy Atoms 28
NP-Likeness -1.39

Activity Summary

IC50 3 meas. best 8.92
EC50 1 meas. best 9.11

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
5-hydroxytryptamine receptor 1A
CHEMBL214
EC50 9.11 9.11 0.8 1
D(2) dopamine receptor
CHEMBL217
IC50 8.92 8.665 1.2 2
5-hydroxytryptamine receptor 2A
CHEMBL224
IC50 7.78 7.78 16.8 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine