Compound Detail
CHEMBL5946226
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CO[C@H]1CCOCC1Nc1cc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc32)ncc1C#N
Basic Information
| ChEMBL ID | CHEMBL5946226 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UMRRXGRLZBOZKV-WCSIJFPASA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
549.6
MW (Da)
1.72
ALogP
10
HBA
2
HBD
159.0
PSA (Ų)
0.49
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.87
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 8.87 | 8.87 | 1.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 | IC50 | = | 1.34 | nM | 8.87 | Enzymologic Experiment of FGFR4: In this experiment, the inhibitory effect of th... | - |
Data from ChEMBL 36 via Core Engine