Compound Detail
CHEMBL5947618
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Basic Information
| ChEMBL ID | CHEMBL5947618 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UUYIKMSUJZXENY-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
430.5
MW (Da)
3.58
ALogP
7
HBA
1
HBD
99.2
PSA (Ų)
0.48
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone acetyltransferase KAT6A CHEMBL3774298 | Ki | 8.85 | 8.85 | 1.4 | 1 |
| Histone acetyltransferase KAT6B CHEMBL3774300 | Ki | 8.68 | 8.68 | 2.1 | 1 |
| Histone acetyltransferase KAT7 CHEMBL3774299 | Ki | 7.22 | 7.22 | 60.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone acetyltransferase KAT6A | Ki | = | 1.4 | nM | 8.85 | Kat6A Assay 1: A. Compound preparation 1. Prepare 10 mM stock solutions in 10... | - |
| Histone acetyltransferase KAT6B | Ki | = | 2.1 | nM | 8.68 | Kat6B Assay 2: A. Compound preparation 1. Prepare 10 mM stock solutions in 10... | - |
| Histone acetyltransferase KAT7 | Ki | = | 60.0 | nM | 7.22 | Kat7 Assay: A. Compound preparation 1. Prepare 10 mM stock solutions in 100% ... | - |
Data from ChEMBL 36 via Core Engine