Compound Detail

CHEMBL5950192

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CC1(C)OB(c2cnc(N)c(-c3cc4cc(NC(=O)Nc5ccc(Cl)c(C(F)(F)F)c5)ccc4s3)c2)OC1(C)C

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL5950192
Phase	Preclinical
Structure Type	MOL
InChI Key	JSYLKKLOSDAHJF-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

588.9

MW (Da)

Availability	Unknown
Chirality	Unknown

First in Class Prodrug

Molecular Formula	C27H25BClF3N4O3S
MW	588.85

IC50 6 meas. best 7.8

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Platelet-derived growth factor receptor beta CHEMBL1913	IC50	7.8	7.72	16.0	3
Vascular endothelial growth factor receptor 2 CHEMBL279	IC50	7.8	7.76	16.0	3

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Platelet-derived growth factor receptor beta	IC50	=	16.0	nM	7.8	Biochemical Assay: Biochemical PDGFRβ kinase assays were performed in 96 well mi...	-
Vascular endothelial growth factor receptor 2	IC50	=	16.0	nM	7.8	Kinase Assay: VEGFR2: Biochemical KDR kinase assays were performed in 96 well mi...	-
Vascular endothelial growth factor receptor 2	IC50	=	16.0	nM	7.8	VEGFR2 Kinase Assay: Biochemical KDR kinase assays were performed in 96 well mic...	-
Vascular endothelial growth factor receptor 2	IC50	=	21.0	nM	7.68	Biochemical Assay: Biochemical KDR kinase assays were performed in 96 well micro...	-
Platelet-derived growth factor receptor beta	IC50	=	21.0	nM	7.68	Kinase Assay: PDGFRβ: Biochemical PDGFRβ kinase assays were performed in 96 well...	-
Platelet-derived growth factor receptor beta	IC50	=	21.0	nM	7.68	PDGFRbeta Kinase Assay: Biochemical PDGFRβ kinase assays were performed in 96 we...	-

Data from ChEMBL 36 via Core Engine