Compound Detail
CHEMBL5965497
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Basic Information
| ChEMBL ID | CHEMBL5965497 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NJLSVJABWRFGRL-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
402.5
MW (Da)
3.78
ALogP
6
HBA
2
HBD
96.0
PSA (Ų)
0.53
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity protein kinase CLK2 CHEMBL4225 | IC50 | 8.34 | 8.34 | 4.6 | 1 |
| Dual specificity protein kinase CLK1 CHEMBL4224 | IC50 | 7.38 | 7.38 | 41.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity protein kinase CLK2 | IC50 | = | 4.56 | nM | 8.34 | Radioactivity Based Kinase Assay: The kinase activity is measured using a radioa... | - |
| Dual specificity protein kinase CLK1 | IC50 | = | 41.5 | nM | 7.38 | Radioactivity Based Kinase Assay: The kinase activity is measured using a radioa... | - |
Data from ChEMBL 36 via Core Engine