Compound Detail
CHEMBL5981172
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Basic Information
| ChEMBL ID | CHEMBL5981172 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KIRCKTNYAUIENF-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
394.4
MW (Da)
2.06
ALogP
7
HBA
1
HBD
84.7
PSA (Ų)
0.73
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 CHEMBL6066587 | IC50 | 8.41 | 8.41 | 3.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 | IC50 | = | 3.9 | nM | 8.41 | TR-FRET Assay: The TR-FRET method was used to measure the PRC2 enzyme activity. ... | - |
Data from ChEMBL 36 via Core Engine