Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q15910. Use UniProt Q15910 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q15910 as the stable identity anchor, then attach disease evidence before program review.
Histone-lysine N-methyltransferase EZH2
Review this target as Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12, mapped to UniProt Q15910. ChEMBL maps the protein component as Histone-lysine N-methyltransferase EZH2. Sequence length is 746 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 as ChEMBL target CHEMBL6066587, mapped to UniProt Q15910. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 is the right protein anchor across sources, using UniProt Q15910 as the stable mapping.
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| Preferred Name | Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | Q15910 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histone-lysine N-methyltransferase EZH2 |
| UniProt Accession | Q15910 |
| Component Type | Protein |
| Sequence Length | 746 aa |
Histone-lysine N-methyltransferase EZH2
Review this target as Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12, mapped to UniProt Q15910. ChEMBL maps the protein component as Histone-lysine N-methyltransferase EZH2. Sequence length is 746 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL6031570 | 8.77 | IC50 | 1.7 | Preclinical |
| CHEMBL5830594 | 8.66 | IC50 | 2.2 | Preclinical |
| CHEMBL5755546 | 8.6 | IC50 | 2.5 | Preclinical |
| CHEMBL5744415 | 8.54 | IC50 | 2.9 | Preclinical |
| CHEMBL5921456 | 8.49 | IC50 | 3.2 | Preclinical |
| CHEMBL6026043 | 8.48 | IC50 | 3.3 | Preclinical |
| CHEMBL5850167 | 8.47 | IC50 | 3.4 | Preclinical |
| CHEMBL5757741 | 8.46 | IC50 | 3.5 | Preclinical |
| CHEMBL5903614 | 8.44 | IC50 | 3.6 | Preclinical |
| CHEMBL5981172 | 8.41 | IC50 | 3.9 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 1 | 76 | 7.6 |