Compound Detail
CHEMBL5986684
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Basic Information
| ChEMBL ID | CHEMBL5986684 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NMWNIWOMIPAOII-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
412.3
MW (Da)
3.98
ALogP
4
HBA
1
HBD
63.6
PSA (Ų)
0.77
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 8.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor A, long form CHEMBL1783 | EC50 | 8.22 | 8.22 | 6.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor A, long form | EC50 | = | 6.0 | nM | 8.22 | ELISA Assay: Four hours later, serial dilutions of 10× compound stocks were made... | - |
| Vascular endothelial growth factor A, long form | EC50 | = | 6.0 | nM | 8.22 | ELISA Assay: About 7500 of 786-0 cells in 180 μL of growth medium were seeded in... | - |
| Vascular endothelial growth factor A, long form | EC50 | = | 6.0 | nM | 8.22 | ELISA Assay: VEGF: Four hours later, serial dilutions of 10x compound stocks wer... | - |
Data from ChEMBL 36 via Core Engine