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Compound Detail

CHEMBL5996307

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O=c1[nH]c2ccc(CCN3CCN(c4cccc5sc(F)cc45)CC3)cc2[nH]1

Basic Information

ChEMBL ID CHEMBL5996307
Phase Preclinical
Structure Type MOL
InChI Key KXLZVZNZPJCJEY-UHFFFAOYSA-N
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

396.5
MW (Da)
3.57
ALogP
4
HBA
2
HBD
55.1
PSA (Ų)
0.55
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H21FN4OS
MW 396.49
Aromatic Rings 4
Heavy Atoms 28
NP-Likeness -1.49

Activity Summary

IC50 3 meas. best 9.66
EC50 1 meas. best 8.32

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(2) dopamine receptor
CHEMBL217
IC50 9.66 8.91 0.2 2
5-hydroxytryptamine receptor 1A
CHEMBL214
EC50 8.32 8.32 4.8 1
5-hydroxytryptamine receptor 2A
CHEMBL224
IC50 6.8 6.8 157.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine