Compound Detail
CHEMBL6002948
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CC(=O)Nc1cc(-c2cccc3c2CCN3C(=O)[C@@H]2CCCN2C(=O)OC(C)(C)C)ccn1
Basic Information
| ChEMBL ID | CHEMBL6002948 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NZGSHAKWURGIQD-NRFANRHFSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
450.5
MW (Da)
4.00
ALogP
5
HBA
1
HBD
91.8
PSA (Ų)
0.76
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase isozyme L1 CHEMBL6159 | IC50 | 6.26 | 6.26 | 550.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase isozyme L1 | IC50 | = | 550.0 | nM | 6.26 | UCHL1 Biochemical IC50 Assay: Dilution plates were prepared at 21 times the fina... | - |
| Ubiquitin carboxyl-terminal hydrolase isozyme L1 | IC50 | = | 550.0 | nM | 6.26 | USP30 Biochemical IC50 Assay: Dilution plates were prepared at 21 times the fina... | - |
Data from ChEMBL 36 via Core Engine