Compound Detail
CHEMBL6006661
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CCN(c1cc2oc(C3CCN(C)CC3)cc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C1CCOCC1
Basic Information
| ChEMBL ID | CHEMBL6006661 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZIADIFPIDBHICS-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
534.7
MW (Da)
4.79
ALogP
6
HBA
2
HBD
90.8
PSA (Ų)
0.45
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase EZH2 CHEMBL2189110 | IC50 | 7.8 | 7.8 | 16.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase EZH2 | IC50 | = | 16.0 | nM | 7.8 | Biological Assay: The activity of EZH2 enzyme (with A677G mutant or Y641F mutant... | - |
| Histone-lysine N-methyltransferase EZH2 | IC50 | = | 16.0 | nM | 7.8 | Assay for Determining the Activity of the Example Compounds of the Present Inven... | - |
Data from ChEMBL 36 via Core Engine